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Successful Drug Discovery, Volume 3
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
Race for a Remedy
How does a mere molecule—a chemical structure—become a drug? And, how do we know that it works safely? In a one-trillion-dollar pharmaceutical industry with high-stakes profits and perils, battles are raging every day to successfully bring a molecule to its birth: an FDA-approved medicine. In Race for a Remedy, internationally renowned expert in cancer treatment and drug development Makhdum Ahmed, MD, takes readers behind the scenes of the fascinating and intense world of cancer drug development. Whether it’s a small molecule, a versatile monoclonal antibody, or the fancy, poster child of cutting-edge cell therapy, modern drugs are built upon a centuries-old solid foundation set by the...
Intelligent Systems'2014
This two volume set of books constitutes the proceedings of the 2014 7th IEEE International Conference Intelligent Systems (IS), or IEEE IS’2014 for short, held on September 24‐26, 2014 in Warsaw, Poland. Moreover, it contains some selected papers from the collocated IWIFSGN'2014-Thirteenth International Workshop on Intuitionistic Fuzzy Sets and Generalized Nets.The conference was organized by the Systems Research Institute, Polish Academy of Sciences, Department IV of Engineering Sciences, Polish Academy of Sciences, and Industrial Institute of Automation and Measurements - PIAP.The papers included in the two proceedings volumes have been subject to a thorough review process by three highly qualified peer reviewers.Comments and suggestions from them have considerable helped improve the quality of the papers but also the division of the volumes into parts, and assignment of the papers to the best suited parts.
Physical Models and Laboratory Techniques in Coastal Engineering
Laboratory physical models are a valuable tool for coastal engineers. Physical models help us to understand the complex hydrodynamic processes occurring in the nearshore zone and they provide reliable and economic engineering design solutions.This book is about the art and science of physical modeling as applied in coastal engineering. The aim of the book is to consolidate and synthesize into a single text much of the knowledge about physical modeling that has been developed worldwide.This book was written to serve as a graduate-level text for a course in physical modeling or as a reference text for engineers and researchers engaged in physical modeling and laboratory experimentation. The fi...
Collective Memory and Dutch East Indiehb
This book examines the afterlife of decolonization in the collective memory of the Netherlands. It offers a new perspective on the cultural history of representing the decolonization of the Dutch East Indies, and maps out how a contested collective memory was shaped. Taking a transdisciplinary approach and applying several theoretical frames from literary studies, sociology, cultural anthropology and film theory, the author reveals how mediated memories contributed to a process of what he calls "unremembering." He analyses in detail a broad variety of sources, including novels, films, documentaries, radio interviews, memoires and historical studies, to reveal how five decades of representing and remembering decolonization fed into an unremembering by which some key notions were silenced or ignored. The author concludes that historians, or the historical guild, bear much responsibility for the unremembering of decolonization in Dutch collective memory.
Myeloma Bone Disease
This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
