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ESTUDOS E PESQUISAS EM EDUCAÇÃO: Saberes e Práticas
A presente publicação contribui com textos que expressam introspecções intelectuais e extrospecções didáticas dos autores e que versem de algum modo, direta ou indiretamente, a Educação e o Ensino numa perspectiva da teoria ou pela prática pedagógica com a intenção de trazer ideias interdisciplinares e questionamentos para incentivar o debate a respeito do ensino e da aprendizagem em diferentes contextos. Tudo isso se revela por meio de novos olhares interdisciplinares na educação e articulados pelos conhecimentos teóricos aos práticos, possibilitando ampliar e significar os múltiplos saberes no campo educacional.
Human Fungal Pathogens
Whereas plant and insect infections are commonly caused by fungi, only a small minority of the vast diversity of fungal species is pathogenic to humans. Despite this, fungal infections cause considerable morbidity and mortality worldwide. This volume is dedicated to the biology, clinical presentation and management of invasive fungal infections. Major pathogenic fungi are introduced by world-leading experts and the basic principles of fungal virulence are reviewed in the light of new results and experimental technologies that offer unprecedented insights into invasive infections caused by Aspergillus, Candida, Cryptococcus, Pneumocystis and Mucorales. In parallel, the clinical presentation of invasive fungal infections and current approaches to their diagnosis and treatment are summarized to provide an overview of human pathogenic fungi, linking pathogen biology to the clinical presentation of disease.
We the Living
Ayn Rand's first published novel, a timeless story that explores the struggles of the individual against the state in Soviet Russia. First published in 1936, We the Living portrays the impact of the Russian Revolution on three human beings who demand the right to live their own lives and pursue their own happiness. It tells of a young woman’s passionate love, held like a fortress against the corrupting evil of a totalitarian state. We the Living is not a story of politics, but of the men and women who have to struggle for existence behind the Red banners and slogans. It is a picture of what those slogans do to human beings. What happens to the defiant ones? What happens to those who succumb? Against a vivid panorama of political revolution and personal revolt, Ayn Rand shows what the theory of socialism means in practice. Includes an Introduction and Afterword by Ayn Rand’s Philosophical Heir, Leonard Peikoff
Microbial Infections and Cancer Therapy
This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. Although such observations go back more than 100 years, use of specific bacterial strains, or viruses, usually genetically modified with known anticancer drugs, and their protein/peptide products, has gained ground in recent years, allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients, often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance, and the readers of the book will discover their impact on fundamental research and promising results from clinical trials.
Protein-Ligand Interactions and Drug Design
This detailed book collects modern and established computer-based methods aimed at addressing the drug discovery challenge from disparate perspectives by exploiting information on ligand-protein recognition. Beginning with methods that allow for the exploration of specific areas of chemical space and the designing of virtual libraries, the volume continues with sections on methods based on docking, quantitative models, and molecular dynamics simulations, which are employed for ligand discovery or development, as well as methods exploiting an ensemble of protein structures for the identification of potential protein targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein-Ligand Interactions and Drug Design provides detailed practical procedures of solid computer-aided drug design methodologies employed to rationalize and optimize protein-ligand interactions, for experienced researchers and novices alike.
The Novel Today
Britain's most important contemporary authors reflect intelligently and imaginatively on the nature and development of the modern novel.
Applied Chemoinformatics
Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.
Who is Who in Thermal Analysis and Calorimetry
This is an expanded and revised second edition, presenting accurate and comprehensive information about our leading thermal scientists to current and future generations. In our globalized world, most researchers in thermal analysis do not know each other in person and are not familiar with each other’s achievements. This volume provides the reader with an up-to-date list of the prominent members in this community. The publication contains only living scientists. The selection is based partly on several decades of the editors' personal professional experience and also partly on the opinion of the Regional Editors of the Journal of Thermal Analysis and Calorimetry.
Tutorials in Chemoinformatics
30 tutorials and more than 100 exercises in chemoinformatics, supported by online software and data sets Chemoinformatics is widely used in both academic and industrial chemical and biochemical research worldwide. Yet, until this unique guide, there were no books offering practical exercises in chemoinformatics methods. Tutorials in Chemoinformatics contains more than 100 exercises in 30 tutorials exploring key topics and methods in the field. It takes an applied approach to the subject with a strong emphasis on problem-solving and computational methodologies. Each tutorial is self-contained and contains exercises for students to work through using a variety of software packages. The majorit...
Commission of Tears
António Lobo Antunes's twenty-fifth novel, Commission of Tears (2011, Comissão das Lágrimas) is set during the Angolan Civil War (1975-2002). Angola attained official independence on November 11, 1975 and, while the stage was set for transition, a combination of ethnic tensions and international pressures rendered Angola's hard-won victory problematic. As with many post-colonial states, Angola was left with both economic and social difficulties which translated into a power struggle between the three predominant liberation movements. The People's Movement for the Liberation of Angola (MPLA), formed in December of 1956 as an offshoot of the Angolan Communist Party, had as its support base ...
