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The immunology of cellular stress proteins
Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins start...
Heat Shock Proteins in Cancer
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Perplexidades de um ano sem fim
Perplexidade é a palavra certa para esse ano sem fim. Ainda é difícil de avaliar as proporções dessa tragédia, pois em 2022 ainda vemos os desdobramentos de diferentes escolhas políticas e de variáveis sociais, econômicas e culturais. No entanto, já podemos afirmar que certamente é uma das mais significativas tragédias de nossa história. E a tragédia é ainda maior pelo fato de uma grande parte dela poderia ter sido evitada: tínhamos condições de enfrentar a pandemia muito melhor do que fizemos, como país e como humanidade. Uma parte das mortes e das possíveis sequelas naqueles que superaram a fase aguda da doença teria sido prevenível com uma estratégia focada na prote...
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Evolución biológica
None
Phytochemicals in Citrus
Citrus fruits have long been popular around the world due to their good flavor, taste, high nutritional value, and their healthy properties. Citrus is well known as a rich source of vitamin C. Citrus fruits also contain many other functional bioactive phytochemicals including terpenoids, triterpenes, flavonoids, amino acids, phenolic acids, mineral constituents, and polysaccharides, which are beneficial to human health. Citrus fruits are generally recognized as an outstanding source of biologically active compounds related to both nutritional and nutraceutical values. Phytochemicals in Citrus: Applications in Functional Foods focuses on up-to-date information on chemical properties of citrus...
Revista Trabalhista: Direito e Processo N.63
A Revista Trabalhista de Direito e Processo do Trabalho, organizada pela ANAMATRA — Associação Nacional dos Magistrados da Justiça do Trabalho em parceria com a LTr Editora, trata nesta edição sobre o tema previamente escolhido para o 20o CONAMAT — Congresso Nacional dos Magistrados da Justiça do Trabalho, maior e mais importante evento voltado aos associados (as), que além de temas jurídicos, discute a política associativa e direciona a atividade institucional da entidade. Em razão do agravamento da pandemia da Covid-19, o evento teve que ser cancelado e retomará o seu calendário normal em 2022. Apesar do exposto, o tema que seria tratado na edição de 2020 permanece altame...
Phagocytosis: Molecular Mechanisms and Physiological Implications
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
HSPs - Ambiguous Mediators of Immunity
Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins were thus classified by molecular weight, as in—Hsp27, Hsp70, Hsp90, Hsp110. More recently, each of these size-classified molecules has attributed a role in protein folding, and they thus came to be known, as a class, as molecular chaperones. However, the they possess properties beyond chaperoning. Indeed, their discovery in the extracellular spaces suggested roles in regulation of the immune responses.
